The Jikei University School of Medicine, Institute of Clinical Medicine and Research, WATABE Lab.


Aversive and affective experiences potently modify brain circuits to guide adaptive behaviors, leading animals to learn to associate negative and positive valences with environmental cues. Our research goal is to understand the molecular and circuitry mechanisms underlying how our sensory information modifies brain circuits, and brain circuits modify our sensory perception.
To achieve this goal, we are employing multidisciplinary approach including electrophysiology, optogenetics, pharmacogenetics, and a variety of emotionally motivated behavioral assays. These techniques together with modeling approaches will lead better understanding of the computation and neuronal mechanisms underlying adaptive behaviors in health and disease.

Behavioral setups

Electrophysiological rigs