The Jikei University School of Medicine, Institute of Clinical Medicine and Research, WATABE Lab.


Hamada S., Mikami K., Ueda S, Nagase M., Nagashima T., Yamamoto M., Bito H., Takemoto-Kimura S., Ohtsuka T., and Watabe A.M.
Experience-dependent changes in affective valence of taste in male mice
Molecular Brain 16(1):28, 2023.
Abe M., Nakatsukasa E., Natsume R., Hamada S., Sakimura K., Watabe, A.M., and Ohtsuka T.
A novel technique for large‐fragment knock‐in animal production without ex vivo handling of zygotes
Scientific reports 13(1):2245, 2023.
Nagashima T., Tohyama S., Mikami K., Nagase M., Morishima M., Kasai A., Hashimoto H., and Watabe A.M.
Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice
Nature Communications 13(1):7913, 2022.
Tsunogai T., Ohashi T., Shimada Y., Higuchi T., Kimura A., Watabe, A.M., Kato F., Ida H. and Kobayashi H.
Hematopoietic stem cell gene therapy ameliorates CNS involvement in murine model of GM1-gangliosidosis
Molecular Therapy Methods & Clinical Development 25:448-460, 2022.
Ito M., Nagase M., Tohyama S., Mikami K., Kato F. and Watabe, A.M.
The parabrachial-to-amygdala pathway provides aversive information to induce avoidance behavior in mice.
Molecular Brain 14(1):94, 2021.
Hamada S., Nagase M., Yoshizawa T., Hagiwara A., Isomura Y., Watabe, A.M., Ohtsuka T.
An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping.
Communications Biology 4(1):461, 2021.
Miwa S., Watabe A.M., Shimada Y., Higuchi T., Kobayashi H., Fukuda T., Kato F., Ida H., Ohashi T.
Efficient engraftment of genetically modified cells is necessary to ameliorate central nervous system involvement of murine model of mucopolysaccharidosis type II by hematopoietic stem cell targeted gene therapy.
Molecular Genetics and Metabolism 130(4):262-273, 2020.
Matsumura K., Seiriki K., Okada S., Nagase M., Ayabe S., Yamada I., Furuse T., Shibuya H., Yasuda Y., Yamamori H., Fujimoto M., Nagayasu K., Yamamoto K., Kitagawa K., Miura H., Gotoda-Nishimura N., Igarashi H., Hayashida M., Baba M., Kondo M., Hasebe S., Ueshima K., Kasai A., Ago Y., Hayata-Takano A., Shintani N., Iguchi T., Sato M., Yamaguchi S., Tamura M., Wakana S., Yoshiki A., Watabe A.M., Okano H., Takuma K., Hashimoto R., Hashimoto H. & Nakazawa T.
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes.
Nature Communications 11(1):859, 2020.
Nagase M., Mikami K., Watabe, A.M. Parabrachial-to-amygdala control of aversive learning. (Corresponding author)
Current Opinion in Behavioral Sciences 26, 2019.
Miyazawa Y., Takahashi Y., Watabe, A.M., Kato F. Predominant synaptic potentiation and activation in the right central amygdala are independent of bilateral parabrachial activation in the hemilateral trigeminal inflammatory pain model of rats.
Molecular Pain 14, 2018.
Shinohara K., Watabe, A.M., Nagase M., Okutsu Y., Takahashi Y., Kurihara H., Kato F. Essential Role of Endogenous Calcitonin Gene-Related Peptide in Pain-associated Plasticity in the Central Amygdala. (Corresponding author)
European Journal of Neuroscience 46: 2149-2160, 2017.
Yokose J., Okubo-Suzuki R., Nomoto M., Ohkawa N., Nishizono H., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M.Watabe A.M., Sasahara M., Kato F., Inokuchi K. Overlapping memory trace indispensable for linking, but not recalling, individual memories.
Science 355: 398-403, 2017.
In 2016 and before 
Nomoto M., Ohkawa N., Nishizono H., Yokose J., Suzuki A., Matuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe, A.M., Kato F., Inokuchi K. Cellular tagging as a neural network mechanism for behavioral tagging.
Nature Communications 7: 12319, 1-11, 2016.
Sugimura Y.K., Takahashi Y., Watabe A.M., Kato F. Synaptic and network consequences of monosynaptic nociceptive inputs of parabrachial nucleus origin in the central amygdala.
Journal of Neurophysiology 115: 2721-2739, 2016.
Tsuji M., Takahashi Y., Watabe A.M., Kato F. Enhanced long-term potentiation in mature rats with a history of cryptogenic infantile spasms.
Epilepsia 57: 495-505, 2016.
Watabe A.M., Nagase M., Hagiwara A., Hida Y., Tsuji M., Ochiai T., Kato F., Ohtsuka T. SAD-B Kinase regulates presynaptic vesicular dynamics at hippocampal Schaffer collateral synapses and affects contextual fear memory.
Journal of Neurochemistry 136: 36-47, 2016.
Sato M., Ito M., Nagase M., Sugimura Y.K., Takahashi Y., Watabe A.M., Kato F. The lateral parabrachial nucleus is actively involved in the acquisition of fear memory in mice. (Corresponding author)
Molecular Brain 8: 22, 1-15, 2015.
Ohkawa N., Saitoh Y., Suzuki A., Tsujimura S., Murayama E., Kosugi S., Nishizono H., Matsuo M., Takahashi Y., Nagase M.,, Sugimura Y.K., Watabe A.M., Kato F., Inokuchi K. Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory.
Cell Reports 11: 261-269, 2015.
Nagase M., Takahashi Y., Watabe A.M., Kubo Y., Kato F. On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission.
Journal of Neuroscience 34:  2605-2617, 2014.
Hamada S., Ogawa I., Yamasaki M., Kiyama Y., Kassai H., Watabe A.M., Nakao K., Aiba A., Watanabe M., Manabe T. The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain.
European Journal of Neuroscience 40: 3136-3146, 2014.
Watabe A.M., Ochiai T., Nagase M., Takahashi Y., Sato M., Kato F. Synaptic Potentiation in the Nociceptive Amygdala Following Fear Learning in Mice. (Corresponding author)
Molecular Brain 6: 11, 1-14, 2013.
Kinoshita J., Takahashi Y., Watabe A.M., Utsunomiya K., Kato F. Impaired noradrenaline homeostasis in rats with painful diabetic neuropathy as a target of duloxetine analgesia.
Molecular Pain 9: 59, 1-14, 2013.
Kato H.K., Kassai H., Watabe A.M., Aiba A., Manabe T. Functional coupling of the metabotropic glutamate receptor, InsP3 receptor and L-type Ca2+ channel in mouse CA1 pyramidal cells.
Journal of Physiology 590: 3019-3034, 2012.
Nomoto M., Takeda Y., Uchida S., Mitsuda K., Enomoto H., Saitoh K., Watabe A.M., Kobayashi S, Masushige S., Manabe T., Kida S. Dysfunction of the RAR/RXR signaling pathway in the forebrain impairs hippocampal memory and synaptic plasticity.
Molecular Brain 5: 8, 1-15, 2012.
Arima-Yoshida F., Watabe A.M., Manabe T. The mechanisms of the strong inhibitory modulation of long-term potentiation in the rat dentate gyrus.
European Journal of Neuroscience 33: 1637-1646, 2011.
Moody T., Watabe A.M., Indersmitten T., Noboru H., Komiyama N.H., Grant S.G.N., O’Dell T.J. β-Adrenergic Receptor Activation Rescues Theta Frequency Stimulation-Induced LTP Deficits in Mice Expressing C-Terminally Truncated NMDA Receptor GluN2A Subunits.
Learning and Memory 18: 118–127, 2011.
Yamamoto K., Noguchi J., Yamada C., Watabe A.M., Kato F. Distinct target cell-dependent forms of short-term plasticity of the central visceral afferent synapses of the rat.
BMC Neuroscience 11: 134, 1-18, 2010.
Taniguchi S., Nakazawa T., Tanimura A., Kiyama Y., Tezuka T., Watabe A.M., Katayama N., Yokoyama K., Inoue T. Izumi-Nakaseko H., Kakuta S., Sudo K., Iwakura Y., Umemori H., Inoue T., Murphy N.P., Hashimoto K., Kano M., Manabe T., Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior.
EMBO Journal 28: 3717-3729, 2009.
Kato H.K., Watabe A.M., Manabe T. Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
Journal of Neuroscience 29: 11153-11160, 2009.
Miwa H., Fukaya M., Watabe A.M., Watanabe M., Manabe T. Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS.
Journal of Physiology 586: 2539-2550, 2008.
Nakazawa T.#, Komai S.#, Watabe A.M.#, Kiyama Y., Fukaya M., Arima-Yoshida F., Horai R., Sudo K., Ebine K., Delawary M., Goto J., Umemori H., Tezuka T., Iwakura Y., Watanabe M., Yamamoto T. Manabe T. NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. (# Equally contributed)
EMBO Journal 25: 2867-2877, 2006.
Bando T., Sekine K., Kobayashi S., Watabe A.M., Rump A., Tanaka M., Suda Y., Kato S., Morikawa Y., Manabe T., Miyajima A. Neuronal leucine-rich repeat protein 4 functions in hippocampus-dependent long-lasting memory.
Molecular and Cellular Biology 25: 4166-4175, 2005.
Nakazawa T., Watabe A.M., Tezuka T., Umemori H., Manabe T., Yamamoto T. p250GAP, a novel Rho GTPase-Activating protein, interacts with NMDA receptor.
Molecular Biology of the Cell 14: 2921-2934, 2003.
Opazo P., Watabe A.M., Grant S.G.N., O’Dell T.J. Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular ignal related kinase-independent mechanisms.
Journal of Neuroscience 23: 3679-3688, 2003.
Watabe A.M., O’Dell TJ. Age-related changes in theta frequency stimulation-induced long-term potentiation.
Neurobiolgy of Aging 24: 267-272, 2003.
Komiyama N.H., Watabe A.M., Carlisle H.J., Porter K., Charlesworth P., Monti J., Strathdee D.J.C., O’Carroll C.M., Martin S.J., Morris R.G.M., O’Dell T.J., Grant S.G.N. SynGAP regulates ERK/MAPK signaling, synaptic plasticity and learning in the complex with Postsynaptic Density 95 and NMDA receptor.
Journal of Neuroscience 22: 9721-9732, 2002.
Watabe A.M., Carlisle H,J., O’Dell T.J. Postsynaptic induction and presynaptic expression of group 1 mGluR-dependent LTD in the hippocampal CA1 region.
Journal of Neurophysiology 87: 1395-1403, 2002.
Watabe A.M., Zakki P.A., O’Dell T.J. Coactivation of beta-adrenergic and cholinergic receptors enhances the induction of long-term potentiation and synergistically activates mitogen-activated protein kinase in the hippocampal CA1 region.
Journal of Neuroscience 20: 5924-5931, 2000.
Migaud M., Charlesworth P., Dempster M., Webster L.C., Watabe A.M., Makhinson M., He Y., Ramsay M.F., Morris R.G.M., Morrison J.H., O’Dell T.J., Grant S.G.N. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein.
Nature 396: 433-439, 1998.
Thomas M.J. #, Watabe A.M. #, Moody T.D., Makhinson M., O’Dell T.J. Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation. (# Equally contributed)
Journal of Neuroscience 18: 7118-7126, 1998.
Smith D.J., Stevens M.E., Sudanagunta S.P., Bronson R.T., Makhinson M., Watabe A.M., O’Dell T.J., Fung J., Weier H.U., Cheng J.F., Rubin E.M. Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome.
Nature Genetics 16: 28-36, 1997.


遠山卓, 渡部文子
特集 シナプス
生体の科学 74巻1号 医学書院  2023年2月,
永瀬将志, 渡部文子
増大特集 革新脳と関連プロジェクトから見えてきた新しい脳科学 Ⅱ.
生体の科学 73巻5号 医学書院  2022年10月 p.442-443,
実験医学 40巻13号 羊土社  2022年8月 p.2184-2186,
味覚による快・不快情動の制御機構 (Neuronal circuits in the mammalian gustatory system)
日本味と匂い学会誌 特集号 24: 81-85, 2017
ペインクリニック 第37巻 真興交易(株)医書出版部 2016年6月号 p. 705-712
特集:記憶ふたたび 痛みから捉える情動記憶の神経回路基盤
生体の科学 第67巻1号 医学書院 2016年2月号 p. 51-55
渡部文子, 真鍋俊也
Clinical Neuroscience 26: 402-405, 2008. 中外医学社


100 Keywords for Reading Papers in the Field of Psychiatry!
スタンフォード神経生物学 Principles of Neurobiology 第8章 運動系と制御系
Liqun Luo著. 柚崎通介, 岡部繁男監訳. メディカルサイエンスインターナショナル
日本生理学会教育委員会編.(問題作成委員として参画) 文光堂
渡部文子, 真鍋俊也
シグナル伝達キーワード事典 神経可塑性 pp.266-273.
山本雅, 仙波憲太郎, 山梨裕司編. 羊土社
渡部文子, 真鍋俊也
脳神経科学イラストレイテッド 改訂第2版 神経可塑性(長期増強、長期抑圧、構造変化)、pp.181-187
森寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川剛編. 羊土社
渡部文子, 真鍋俊也
シグナル伝達イラストマップ 神経可塑性 pp.266-273.
山本雅, 仙波憲太郎編. 羊土社



Watabe A.M., Ito M., Sato M., Sugimura Y.K., Takahashi Y., Kato F.
Synaptic inputs from the lateral parabrachial nucleus to the central amygdala is actively involved in acquisition of fear memory.
Gordon Research Conference Amygdala in Health and Disease” (MA, USA) 2015年8月 (最優秀ポスター賞受賞)
Watabe A.M., Sato M., Nagase M., Takahashi Y., Kato F.
Nociceptive Amygdala is actively involved in Fear Learning.    
Gordon Research Conference Amygdala in Health and Disease” (MA, USA)
2013年7月 (Hot topics賞受賞、short talkにも選抜)


第40回日本神経科学大会 教育講演(幕張)
情動の神経基盤 ~ 負情動という「価値」はどのように作られるか?
Watabe A.M., Sato M, Kato F.
Nociceptive Amygdala is Actively Involved in Fear Learning.
Watabe A.M.
Involvement of Nociceptive Amygdala in Fear Learning.
Gordon research conferenceAmygdala in Health and Disease”
Short talk (MA, USA)
Watabe A.M., Kato F.
The role of nociceptive amygdala in fear learning.
第36回日本神経科学大会【座長:渡部文子、Thomas J. McHugh(京都)
Watabe A.M., Kato F.
Synaptic Potentiation in the Nociceptive Amygdala Following Fear Learning in Mice.
Watabe A.M.
Roles of NMDA Receptor Phosphorylation in the Amygdala